The Secretariat, headed by the Secretary General / CEO, is responsible for implementing the policies and directives laid down by the Council.
| Name / Designation | Appointed on |
| Mr Benjamin J William Secretary General & CEO |
1 March 2012 |
| Ms Charis Chan Assistant Secretary General, Operations |
16 January 2023 |
| Ms Eileen Cher Assistant Secretary General, Corporate |
|
| Mr Prakash Menon Srikumaran Group Director, Blood Donor Programme |
|
| Mr Sahari Ani Group Director & Dean, Singapore Red Cross Academy |
|
| Mr Adrian Lim Director, Care Services |
1 January 2020 |
| Ms Iris Choong Director, Corporate Management |
1 January 2019 |
| Mr Isaac Tiong Director, Finance Management |
